TL;DR: 5-Amino-1MQ (5-amino-1-methylquinolinium, also written 5-amino-1mq and 5 amino 1mq) is a small-molecule quinolinium compound studied in vitro as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). Transparent Peptides lists it in two vial sizes for laboratory research use only.
What is 5-Amino-1MQ?
5-Amino-1MQ is a methylquinolinium compound with a primary amine group. It is used in research on NNMT, a cytosolic enzyme that has been studied for its role in cellular metabolism and energy homeostasis.
NNMT research background
NNMT has been examined as a research target in several published studies. A 2014 paper in Nature reported that knocking down NNMT in mouse models altered responses to a high-fat diet. A 2018 paper in Biochemical Pharmacology characterized membrane-permeable, selective small-molecule NNMT inhibitors built on methylquinolinium scaffolds with primary amine substitutions, the structural class to which 5-amino-1-methylquinolinium belongs, in cultured adipocytes and in diet-induced obese mice. These are model-system studies, and nothing on this page suggests a use outside the laboratory.
5-Amino-1MQ listings and specifications
| Listing | Format | Storage |
|---|---|---|
| 5-Amino-1MQ 50mg | One vial containing 50mg of 5-Amino-1MQ as a lyophilized (freeze-dried) powder | Sealed vial at −20°C, protected from light and moisture; allow the vial to reach room temperature before opening |
| 5-Amino-1MQ 1mg | One vial containing 1mg of 5-Amino-1MQ as a lyophilized (freeze-dried) powder | Sealed vial at −20°C, protected from light and moisture; allow the vial to reach room temperature before opening |
A certificate of analysis (COA) is available on request for research records. Both listings are sold only to qualified researchers, with shipping to the United States and Canada.
FAQ
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule quinolinium compound studied in vitro as an inhibitor of nicotinamide N-methyltransferase (NNMT).
What sizes of 5-Amino-1MQ are listed?
Two lyophilized powder vials are listed: 5-Amino-1MQ 50mg and 5-Amino-1MQ 1mg, each as a single vial.
Is a COA available for 5-Amino-1MQ?
Yes. A certificate of analysis (COA) is available on request for research records. Contact our support team with the product name.
How should 5-Amino-1MQ be stored?
Store the sealed vial of lyophilized powder at −20°C, protected from light and moisture, and follow your institution’s SOPs.
Is 5-Amino-1MQ for human use?
No. 5-Amino-1MQ is sold strictly for laboratory research use only. It is not a drug, food or dietary supplement, and is not for human or veterinary consumption.
All products referenced are sold strictly for laboratory research use only and are not for human or veterinary consumption.
